	   SnapGene      ‰GCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCACTAGTCCAGTGTGGTGGAATTCTAATACTTTCAGATCCAGACATTTAATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTGATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCTTGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAGAGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGGTAAGAACAACTCTCGAGTCTAGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGT  3                                              *                                                                                                                  !            $      "   )            "            !            
                  "                        4                                                                                                            
                              #                                    !      
                                       	                                    *                 !                                                                              	               "   (            #                                                                                                  )   "                           !      "         ñ yÞ­ÄÅÆËÐßà/89ÝÞ
¯
r¯1O¼>ï+= yzœ¸úN®áê®P	Ž
“
§2�½?<äƒî»o – ò �ßÇÌ:cë
µ	°Pð•> · `æÑ0ß0Ð	
d
£
°
sL Ò„èD,Ã C “�ûO2<¯âY'	3	Q	¹	?¾åp •ÎbÈsšë!�ùX�
EÛ9�Joõ=r @„¤¼Ì f{¹jÌå¯f	x	~	™	µ
AZ«î 3@"ûÏ0ï<j z¹€Öo@
”
c¨× �D÷’w´ÈÍ	diS¶	,
ØQÆl+É¥– $žåêsþ;f%_µÏô
Q~ŸÜ — Lmàïlì$DÇ¥	
±üj¯Æ-¥ñ&e? F ó þ˜LûûrñxU3  œ açîR`	
e
¤
ó
–¦¾BEðÃÓ	"ˆÉèEÍã-Ä o ®õR©Òù(pÑ	F
±
ç�—Ák¨* t 40\?à1Äàdß*	<	¾	Æ	á	ú	N
W
™
å
ö
	t�&M–…9éá ¸ +ìé1¿ü	6	­	[
âý±_j|.õEP D ü=˜ãú 	%	(	4	|	¼	D
©ÁÄ•æ P3wr	º	Ô
Û¿"¾Lq M ”ž¯Z™@[ÄynŒ¨Ô X y°ÂÒ	R	15j<£ê4_W§I™ ˆ Ï,É÷tì,t	‰
�
§
Fg9:ö>&CbØQAP…F¥ö 8U›"YÖ
$Ü¶ø‘KÌsÇ0Í-S ‹ –Ú!cìú4
ÏH¬8À½Õ"  £ëò&‚�	8
‚Op‘F  ° Gºæž¹Í!y	–	ê	é
B[Á!”X ½ gû5F=0Aá#Ößð Ï |Òkyæò¥°¹×Œ	š	ïuÝãü¼$% €§ÿ*g	l		¶
U^¬$4ˆÐÛã1=¦û;=Nrks{ Q]†Ùâ“ÝASA
a
}
d£–Ç¤·öag } É ­�×ït	Ú	ÓÔ}Ç Ö {rºC�4pãÌ	•
÷©íØÙÆ¡ y 8CRÈm{	
#
·Q»¿Þ£Ð ‘dø�“·ÌÉÎ
gj.m÷V·	U
Ùû	­ÇC),þSÇ Eä¡éðy#	µ.]U“Ÿ¦— < > »ñŽµeþ Tó	Dm‰ÑÊWÅ R ä8bxø-
w
ª
]R›‹üfX O ë/±M+ 	\o Ó’ å %mŸæÊÿóF&u¶ÐõpŽI�[ + `–½-</wX	Ú
gÄÔÍ`KRfÝÇ& 	 ³ ²Ë#Vót;ª @ Æ áBPV€
#ýªt‚{¿}¯²?MÖIÒ " ˜ Û mÈk.i��'Yf Ÿ Mn ¤cSEƒ	W°Ç‹ë¦®T¤Ø� û dð½í%bwÈ¦	õ	
h
‡›²Bÿhvš ´•ò$T@ G ÇR²ÛŒ˜üsÎÕd ô T‰Ü3–·ÎH�þ	
ƒ
¾
üÀÌB„¶æ …ÿ«™MÐ¿òy«r ‰†\]�(
´*ÆV4 JkèP^aL
Œ
ñ
ô
C¥/ºÄ#£$Ë V ® ê¥
"3§¿FÅ
Ê¤Î.Å � Ä bïawf
!ñrË€‰éAä� T ¤ FS\rŒ”


J
o
y—™}-w¸ÔõFªXÂK¨ùE! ¯ S	¼¿Óöt%)mq÷¢	
=
G
q
²
z^Gèë¶¹ÄMTl Z p àK…úÛ3L{”C	ì
wYdŽ².[ª›©³  „ ö²¡¦úU8<€„ˆ	ú
,l›}”¢=¤©Âtzù   ª½ž	Ò	7�˜ohG$ J ¦ 5Yáæ'þ,Ôàâ	û	X
t
š
æ
÷
6N<¡ò…Y�†§_œþF e 9]@	¿	Ç	O
�

'æa:ˆ»" 8 u ‘ © )1oÄÐ£Åú+	=	T	±	 Èæ>U_aì„ÞHŠêâ—)  1 {Ö2šÓáeJ	å	y
Ë
u�oyÖæ÷—ºùSzZ‚ùÑì+Ù  Á¶ý	®	í	ð	¬
Ñ
IÌãþlì6}=F€Q° ' ¹ rÆÄEIzˆ¸2\
{‹Ó�²`káîe9™µ‰ûZ 0ñ/:dÀ		7	Ä„ŽïKT.¬/Âg" ,<J¦ÏíýÕêWHŽ–8L¢®·ÃÍØ
/
ŸÊI€œŸöß • xMÞ7ê­	
’
q=çCºÂ< 1aË™Õä&	w	}	?
´
YªInÖúÎ/;£ E ýîýv³R¤	ûÅ^q	! n s › í>ßø'coû	)	5	;	½	E
Ž•Â!^i{•ç–À § Áùq	»	i;éÀÃx‹ Š  Tö%+s	Õ
7NBEÆ×OE¿, ¼ ¦Ñúþ4Ex•	Üà»Ú#<Õ$“Mr
 Q¬Çî@s	Ù	
Ó Q º�÷-l"	©
C\(ý’ûRVÄW  * N ä l•±Ê"U.°.v	Ù
Jeo�‘H© ! Ú ú ŸAÇšA©ghzS€¾”œ£LÕS 2„ˆ[G\�œ‹¿Åqµ j`O[v‹“
I
‹
!2 |¤Ä,@¢£J#Œ" Y J„±¾ùÚõ$7Kl“6kv|“<Xc¨ê µ¸-nyšø d XnzÃÕ+ÒÓ	I	S	s
=`åë` øR€�‡ë* & .HH~5Jžíd8< m r `ÊüuÝ¬‘
”ú ]hzÍ.Bÿ:¦¹Á ‰ ÐùDSí$p	”	
h:MßÒDwÖÙ’ ¹Éƒ--[u	¨
Ø
B¾'RdQ�GK´V % c WmIøZÑ6~H	Š
 GÃu’;I÷?c´†"÷ øCR_#5Z}G	×
ùt‘AHL\gyÞvÌ-c!¸U4 \ ¯Â÷&V^“ËÌÍßàE	F	Ý[fwx°±tuÈÉÊË+,KL 1�ž«µ¶·./T ] 'è°Ãâ9W‡”œØÎáÞ·p„�²FMY¬Î08 ¡g'!|%¸’Í�”r3 2Ÿ4 (ZŒßé]™Äã´ÛŒ•Ïû5
î
ßI¸gÁX©N‡­Ï# á Wu>��òiÐqyŽ(0 Áéó¾Öí19 ^ € ë :—8MXˆ�âíñC‹ç…#nGyx  Œ ç ±"dqÙÝ		õ­9³Z^Ž @oµ×çµD¬ø! j Ìóƒ†Ü‘	Ö	&-P÷G‘ 5 ¢Ïh(ì}¨½9
ƒR¹d¸3sÙ]3n !¤"'�N–Î“qÎ’Ê•4°] 
)�êB^šäÜç"Ý—	ã
C¼ÖàJhùßciƒ † [àu�–Ðz	Š	Ê	6
\¹ö"Yª Ol ± bÅµŸüÂÎSYÐ$  ÄûH»ÂºÎü1:y‚õë	ê
ï
�Â:ˆ‡•É®  â ÿ jvhKüó>jšzÿ“P¼¡Â : X6Go‘ªer�?BÜ×1vñ¿2 ¾ ÂZ	Ñ1hjî À ?žü
Ö0)â$àêô×Ý � Ì Ó NƒÖ�Ú9ªž¨çÄ�	›	 
3[oÏz¸ó Ð Þ ì ÷ ø/<;l‰WîDŒk¦ý½%Hvð _ ˜}°Ó	NYzó¦±ºØãèñ`	Þ†–M¯&û(K ˜´º¿�òÑ	Â	ðvä¤$çy¹ 65£Ú5€	Þ	R
).ôi�‹
®´¼ÞÄ<l è ¶¿Z²#r+m	à
VnÓÖ¾Ëö:«([�*ü\ÿ  - � 'eÚL“>†h	·
Á
_­5ÆbTÑä2_ž§ñ>s|t �¨ >²\	Ü
%1±‰Ü>¸cmŒO| µ ï "œãw¶õÿBb
¤d+7íâìÊh AAØB
_
e—Ù2¥�×Ýù R^‡Ú+”»)T`~
9­"b Â pÍÞDpè 	þ
È¶E¸WÀ÷Ï ‚ôØu	×	5ÔøH~¾¡  h k ~ Íð„Ý’	Ô	Û	n‚‹!+®’6 Ê ´%X®'.iQ	þI ‚‡)Õ=È £&-)í5ƒ~Í	:
†
–
„øŸ}êäñq�¢o
 × H…äÙ¹4?Ú |ª»i �„SÚt^ƒ  sÐD}q‰©¾=ªºeî	Ç_¬4bÙß z 9vÉ| 
R¼éØr¤™	ÑöC ?¬¿(O—Àä–„î5±‰ 	¥$
Æ
Ïß”&l8š] D‹"S•#n
Ž¸*MÏ“Ë^j Ž_›åùÝ¬ÃÊÏé ./´	Ï	¢
K®ÿNÑƒ” B ’e”¸Í;iÇrXn€øW2	˜	¸	DbÚí>ôÿ Cr‘hk#Æ×i®úó*P}žwTÈÛd¤„# *3­ëôQ¨/[èÞV
Z
˜
ä
½áü
%Aï‡ÈDæ-ôàOj L v—®Ñ	$	{	¢Z^VÃ!m”§½K˜ ‡ +¢êñ�	3
7
ˆ
8÷«%aPÔõ!  Î Få�¸) <¤Ök	‹	é	è
]/#‡âq x È Õ 7P\…Øáq’ÜŽlzRâË	¶P•ºì£õ|Å ` ; = �¶ã ãèï7föýÿUv
ú¬TˆŠž ² ¼òLW	ÃÓE[nÒÆZ% ? c£ORvô	†V­|±XHÑ Æ…ª¶ý	
'
‚
½
Q³Ï—)ªËAƒ
 S £ In
ð
qvÊô©W§Ê ƒ ¼» 2;zƒöB	�	<
ë
ù
]¡£Œ± Zsg  0 7 � ¨ (Ïåýùä	x
œ
Ê
Ç5^;„^‰ýº–Ø!  ¥ÅüÃ9DVcy‡µ	ì	.
«
Ð
žÃËÒSœÁ´ˆÞ¯Y ” š wìL0~Þ²6é:	”]p;
 ý?èA;ÔŠ+   P Ù ã ù k1‡@ö,kFŽ›!	¨½“¢Ã  i_ôN’{ä Qÿ€¡) $ b lH Y«Ñ�J‘À & çfBQ] ’×Ês�@GvÝEJXbq23 à æ Y=œ³7p‹�hðæfôWm¨'�xŸwò nËÖÛæ§¼cC·ö2Ø\ 	aÃú0xôÉ	õkÞhÈ‚ ¿ Jn©Y	dÕÛgi Ò Ý —Õ.;©¾œÃð	Á	Ÿ
2ZÎL®uïò' , ¾4=’[	Q
Û
ÒhŠÅÊ0a°»ÝS'�)b[þ ´ Á î !›Ì*ô@oþý
c1*6¿ìÜáë 
 g ³$W�m<½	 ,Ÿ<€«‚ØÞ >u”)×ã%kƒíõB A ¬P§q:h«ÆèWÅ1	³	¡
$@þîÐO|vÚN w Ç Í Ô O„×p‘ÛkQ£Ž	”Â$†áJÓô  : ¢âQ©uV	
�
PU«²¬{°@	 ‚ ¢ CUŸ†´A	œ	m
É
Ê4\puÉƒ°À~¦³¹×Ý “ ™ ø 0}ÝèõE�þ(* # a ß <ek²ÕP\ŠXgÉÚåïl§DIWŒwž Ñ Ü ù3m¨¨ïóYcÉ/¯Ü&(aZgñý í  š=+“nýblj¾‚ìA� ¡ Oo¡¦TP¢³0	@	
±ÈN«¯à¥Ù ` ™d±ÔO[|’çôüf§ÙäîòaXCV'`
€ü)*   N¥
Z{FG¡²éêëìí-	.	/	?	a	

è—˜™šŒ�§¨©ªçBU™çè  ~~½¢ŠŸ¥²ÇH»b	„	éß‡›†Žì1Jè°š…�éL «  ¾I¼c	…	Ã	ˆw³àF 9iwo±–0(U ü £ôÒ&ñˆœ›5µäèv†ê  ™ñµ=»À¦³cžóÒ§	
ê‡‘œŸòC¥2K!éz›º%‘! e¾™g‹©®ÈîxÉ	ö	i
Wå%‡Úà�íóãAM }Û–½d	Ä	ß	?�¯ù:jp1)m 62{
/Sõ´áÜµVe È�	S
°³[™ýÿt½²ÏÅÓÖ=d H ¬ 7¤¡¶¿6J†	*w‰jx‚ŒGäðxß—  ¤Ó,I‘ÿ	Wo;Áeœû�¡+éCw  é UŠ·Ý[—³õ$Ï‹A‰n	
’¿¼Ô)\ý®ç8ë õ ý À4sØ¸¿
á
Ôò8¼Ì÷ýN¶åa…·Û uF'„
Ä
×€‰�g{è¬U6Í]‡   . Ž ¶M¬Áô			i	ç	`ë ¬ÑU\óz¨òœ»’ ( š>¼4Õšˆó¦âê`¬s òfÛ§dsŸ
N’�DÇØÀ"„å3}Û&?t}á  †
´”?‡Ó¨	¸
Â
®63LcÒŸ{6u Òï«ÀÊÕª	÷	)
Û™+²Šdî8�B €€ˆ¿‚Š©]y	]	Ý
æ)µ&ˆ2�|Ç¹!jnP šh‡Œœ¯j
º
Í
X&á	Ý?W-5ä 3 f\?ªÉã^gž³L	qîû5ÉôNw} ¶ ð x·bÜO	c
�
®
¦0Ž»;îã‚í*n ~ e	@8!q?Ëi #�äKléöC—
+
KeÅú$,k´Î¤ð%2 Q_Ã ¾¬	Å	à	ù	M
ò
õ
¥ D°8ŒÌâ W xÿC
Ó
04¨˜Ú3¦HÓ 7Ùë¦
#f�ÎGµË�/R ¯ ñ¸TÀtâ¥Þú:Wz | BB3"
`
|
¢ö¾ÆÝ¶Ò¢ØÏÆf cðËaxò	T
´-\š BÐÆe	 _,É*:òÌt� ž Å b¼Ua‚	g

"sþ�Šêu™³®×>#Ž SˆÛ•Í±Ú¾ÍÔåc U ­ Ã E]qéK
x˜.·¹ÁøD  ß¥Ts‡	¡	
p
+šy~FÃL©S²F" I ¥ 8&~™¢°	ÿ
åTnxƒÕÝåñö¹GXy¦Y›øÐE( /;IqÎðÔG�•·À7K¡­¶ÂÌ×	ï	
zŠkƒ�ÉëîH›-«àf˜ú íÔ÷&Qbnv	£	
>
³
Xp�<HmÕæù¿¢ » 
¥«ÆÀõ*rø	Ø	6ÂºÅ#ND  ) ° !TŒÆŠfIgü‘úp›UR# ƒ½Ô-GÙ*uŠ#Jk’ 
H
r
}{+_Ÿb�éì·¢,7;êmx‹ l q ¸È‚VûÜÐo	“	
“Â½~³Õþ³9 [ ®Ááö%†{Þ4|D	oƒŒ·Ze¯�“*œª´7   ê Vt‹Þ\˜LñBŠÜ	í
xÀ"]†/èì i ?´Î…ŒM•Õ	ÍQ,´É\«÷¯m … AÁtû9�Ü‰	â
œ»Õ9ÍøR
b†  þ iÁ™û
þ/>’O»uÿÜ Ë ö M‚÷�Ù¯³§¹VÐ_	•£j¥·æ¸úJ µ&5YÙK¢4=…±À
ß
(-mó€Õ~½ª·ðlÃ‹{ vCº(_Ÿ	^
8ØVŽÖÎÉ Ó	�Š (*h4­ýH  ©%G„|‚ƒˆ…
ž|éãð>^pa Š«¾Å
èL˜7™iˆ\ 2ó.ZqÂÿ-Î	Y
—
aì­=M†ó‚åò�ó£“  K 6*œ·(­;Õá	j	è	2
‡
ç
7O¡ë¢`ô{Ä¼p_ âçî6N„Kõü	&
u
¼
…ùÒ
–(Z‡©‚�G  / 6 � § ¤'
	ã	;
›
Ï
ø
ÆÑ ~¢ó¨V]ÿYr Ø ^†?5‘9	§ãç@:‰ ›AŽÖ¦»åVb1a Ô:I½‘›Â	À	È	P
ž
‰ôÚºœ­t� f )€(5;ëÛ¼ 9 v «pgÅj…tU	²	l
È
OÉ?“TíÁ#…uÜ ’ *2j§ÜbÈ®Û‹ë~@  }¼¡‘‰ž¤±ÆæûOe ,	>	
ç`…0IßæA_˜	~„æ ª ó˜Ñ<f¨­V†�žñEÙß8n4ã/'uâ |1µ•z
>v¯ZãïøþÒc   tE×Š@ˆÃ
‘7»fzç»MTdÓú
 `­7Ú   	3Ôr		æ	«á×[ƒ|Ú5à 2 ‡Ñ[~›âfª¿ÔK	©	¹
Ì
p(˜ú4{È ií,7v ÂN	«	ø	
*
­
Jÿ7 ³Í‹>�ïá { wð·þ!
Ò
€¡Ís½Ñ¡G9ÒQy Ê`Ìñ	,Ùs˜ÌŽ)  .:HïÓ%}˜ ¬µÁËÖ	¯	î	äSmêí‚Ü~š,¥š
eR÷D±C" ( º ÿ‹ªÅìF)‰"PajÅ	|Œ*‰žalåfù"6:ošQŠ >sÇ�­ÀUzÁÌP¶³}È…ö²l Lh�@ŽØÀJ3˜°ÏÛ^	Þ
ºÔ‘ºïk¶Š ¨‰$ƒ{�B¹^]
çK'3âï—ü`[ 5 1ò›pJ:%
1
»
Î
ÅÐ	L•¡ò
'ÃX^ Ó���Á¥º8	U09›€ 
—¦;eiˆ�¬°åNk
Ç
…�ð/7­mÞ@.å 0Z		Y'àâýh6 -Gî$_—ËŸ´M	
 +r�Ð— ÌËàPx! =Kg§þ�×#Të€A!`i¯ÄÎÚ¹ËJOøõ_k 4 Ò–YoI�«ä9M�¤¹0
 ñü6" EFÐÑŒÖX]^@Ê _h£¸ÙN�žŸïð”•–Ê÷O~  +,  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                            #                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    	                                                                                                                                                                                                                                          !                                                                                                                                                                  
                                 
   	               &      
   
      
                              	                        
            	            	                        )                              j   J                     H                                                                                                                                                                       #                                                                                                                                                                                                                                                                                                                  	                                                                                        !                                                          
           
 	     &  
 
  
          	        
    	    	        )          j J       H   gN  h*  h@  hb  l   o¼  têS
·Å(Å¦I�Öñ	*³as0Æ²)qY) ì}
ìÏ^£,¦í=] 	£ky	y	Y¾3{� ,¦ÆíJbþSUš¸3{®ý	û	O
f
ñ
÷
l�¿ÊKwË€¹=‹\G¶
Æy¯¶
Ô
Æ¶
Æ¶
y¶
g	A³»ÃbÉalZLé§l	U^k„wcc‘ Ög9Og	}¤d	i	8Ø1rm¨c5	Q†Ù“aÔÛdn
§Ï¢	s©©sw	
,
Q—˜m£¬!¬	Z
áü°O] –Wá„*‡
7`ÑuQ†Ù“	
ÇãajÂ Q× …yw
5‹f†‹f†M	Þ ;‰îk¦v8	³]Ð	-
‹f†Z
y0ßsØZþc	
ìú8€›<Ú
")k	Í	þÄøIK;
Z¼‹“	
ÓEr©swàìd	
,
Qo–—õñ?=( Á‘»Ó7:P*(8@Êëo`Ûþ8	M	­
ºLñ²¢)
²îì
·ÁIþ—%	¬	!iþ,�¬	ú¢:Ï@Ûº¬ y0ßÐ	-
w
5s‹f†sQÔ@Û8	º×àg9V ,íY]Eöúˆ–Á%8m€ž	X
3u{—›ÄÈþ€�
`…²9@ÊÛºú8€›Q*¦þf	µ
«3ÏÚ0<<Mr® ¿5¢4(€T%ž|pM	dO[CV
Ò«ÀÊÕ™+dy*‡
7=`Ñ( u½#ké·]–:‚ÁÆ ÛdmÆ Ÿñ¡éð%\mÔÛ‹pfd†¬ ©sš
	n	
W`³ëq’×�:À"„Ô!mw Â Ç@ VÁþ%*r
Ÿ¥šDýÑ
F;
*r
ŸÛdj‘»ÁÓ7íSy 
»Ði–ù1Ž´	” ±"U©[kÆ%idf	~	µ
«3Ï0<j€§ÿ$ˆÛ=N{1òìpPaŒLlåò…Pr	¦ ¼tâ	G
q
š
÷
z^¡ò§èë¶þl· +ìé0õDU3M	N	
­
Ì�àD¥–Ä
6‡U3¼tG
q
z^èë¶l¦ â	š
÷
¡ò§þJ3°Þ
ÔïkŠæ!–	Bÿ¤7ð	 ¦ ¼P^t	®	â	í	G
L
q
š
ñ
ô
÷
ãClzì^¡ò}§èë¶þQlË°1òìpPaM	N	
­
ŒLlåòÌ�à¡<„,l}©Âz Gº¹Íê	é
Á”-~Í	–
äñ¢( ÿ‹Å‰fùošQ¹Ìx	AZ ±·l‹ dú K ­	¡¼y¸“
§]�"œãõÉí5ƒB„ødØ+rH~� K ’ Ü­	¡dú ¼Œü‘úU%‚…
ž|éãðpÝÇ·öä-Gî$—Ÿ´�aŒ
¥/º‹ rC!cZpïu©ã¬í8ÄÆ`
|
¢±ÆÚ¶ÍÔcf }¤¶¬ï	d	i	ç	? Ápóz8C»—;e¬…�ð7m.Ét�
A¥mÊmyƒ
µk¶õi�ÌŸ[ˆ Ïìg9CØò§�DØ3&táZÄrCp©íÆyƒ
µÌŸ‹ !cïuã¬8 P^	®	í	L
ñ
ô
ãClì}QË°%Œ‚…
ž|éãðü‘úUp† 6
öªOü ñµäÊh�U ­ Ã E]qéK
x˜.·¹ÁøD .:HïÓ%}˜ ¬µÁËÖ	¯	î	äSmêí‚Ü~š,¥š
eR÷D±CJkèP^aL
Œ
ñ
ô
C¥/ºÄ#£$Ë	 ³ ²Ë#Vót;ªd XnzÃÕ+ÒÓ	I	S	s
=`åë` øR€�‡ë*T ¤ FS\rŒ”


J
o
y—™}-w¸ÔõFªXÂK¨ùEØ ^†?5‘9	§ãç@:‰€§ÿ*g	l		¶
U^¬$4ˆÐÛã1=¦û;=Nrks{¸ +ìé1¿ü	6	­	[
âý±_j|.õEPÂN	«	ø	
*
­
Jÿ7 ³Í‹>�ïá… AÁtû9�Ü‰	â
œ»Õ9ÍøR
b†& d t ¸ +4ì0X\nzé?ÃÕà.H+1ÄÒà1¿Ódßü		*	6	<	I	S	­	¾	Æ	á	ú	N
W
[
s
™
å
ö
	Ht~�âý&=M`åë5J` ±_j|–øR€…ží.9d�éõ8<E‡áë*P … ¿ þ 	aiÁÃúAJÁntû©09x�™ÜôY	‰	É	â
û
œ»Õõ9dÍÕøþ/>R’ÛOgik»Þ
bhu†ÈÿÜ‚R^‡Ú+”»)T`~
9­"bƒ ¼» 2;zƒöB	�	<
ë
ù
]¡£Œ± Zsg‡^ € ë :—8MXˆ�âíñC‹ç…#nGyx0Z		Y'àâýh6D ü=˜ãú 	%	(	4	|	¼	D
©ÁÄ•æ# a ß <ek²ÕP\ŠXgÉÚåïl§DIWŒwžE d R^‡Ú	+”ýXnzî¥ÃÕýv³+»Ò)T`ÓR	I	S	¤	$
s
~
Æ
9=Ïû`ßåë`” Åø&R^q€	l�8š‡­ë*"]b62{
/Sõ´áÜµVe  Ø     ±  |         |7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÞKÒ �k–z´oGjX��ö= Q©q`
!ƒô+­Tdo�š¡…ZWEµ^�FZ9Q”Ö¥EZ¥P[ i–ØF©MZXzŸëáˆ_¦€k†4Ñ::Ó¶é#ˆ^!tSS±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  J<?xml version="1.0"?><Features nextValidID="14"><Feature recentID="13" name="æ­£å�‘çŽ¯åŒ–ä»‹å¯¼åº�åˆ—" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="925-936" color="#a6acb3" type="standard"/></Feature><Feature recentID="12" name="HOOK3(human)-circRNA" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="937-1279" color="#a6acb3" type="standard"/></Feature><Feature recentID="11" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5518" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4727-5518" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5519-5587" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2431-3225" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3971-4556" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1593-2021" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2035-2364" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1323-1547" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2215-2350" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3399-3520" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5588-5692" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>ff78c584-a3e1-4c98-ae91-a20e1b04a45a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="5:31:56">2023.9.22</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Ã<StrandColors><TopStrand><ColorRange range="0..923" colors="black"/><ColorRange range="936..1962" colors="black"/><ColorRange range="1963..1964" colors="magenta"/><ColorRange range="1965..5755" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..923" colors="black"/><ColorRange range="936..1962" colors="black"/><ColorRange range="1963..1964" colors="magenta"/><ColorRange range="1965..5755" colors="black"/></BottomStrand></StrandColors>  ¯     ®  p         p7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÞKÒ �koGjX��ö= Q©q`
!ƒô+­Tdo�š¡…ZWEµ^�FZ9Q”Ö¥EZ¥P[ i–ØF©MZXzŸëáˆ_¦€k†4Ñ::Ó¶é#ˆ^!tSS±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ~<?xml version="1.0"?><Features nextValidID="13"><Feature recentID="12" name="HOOK3(human)-circRNA" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="925-1267" color="#a6acb3" type="standard"/></Feature><Feature recentID="11" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5506" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4715-5506" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5507-5575" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2419-3213" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3959-4544" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1581-2009" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2023-2352" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1311-1535" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2203-2338" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3387-3508" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5576-5680" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>ff78c584-a3e1-4c98-ae91-a20e1b04a45a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="5:31:47">2023.9.22</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..1950" colors="black"/><ColorRange range="1951..1952" colors="magenta"/><ColorRange range="1953..5743" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1950" colors="black"/><ColorRange range="1951..1952" colors="magenta"/><ColorRange range="1953..5743" colors="black"/></BottomStrand></StrandColors>  Ž      _  4         47»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÞKÒ �k�½7H0ó±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ¬<?xml version="1.0"?><Features recycledIDs="12" nextValidID="13"><Feature recentID="11" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5190" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4399-5190" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5191-5259" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="NeoR/KanR" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2103-2897" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3643-4228" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1265-1693" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1707-2036" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="995-1219" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1887-2022" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3071-3192" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5260-5364" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>ff78c584-a3e1-4c98-ae91-a20e1b04a45a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="5:30:45">2023.9.22</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></BottomStrand></StrandColors>  ”ý7zXZ  æÖ´F !   t/å£à?ˆT] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷¿Û{î��•ð¬Xûž$Ãóz²´
ƒ„†fsÅ»Î¢¥	hµuß³ç-‡£3‰<õ4$ÃÆ¦úräö¨š£¤øZ_‹(àpï¤&jsãSié‡ÒëþŒíÕH´ð¡(ùÉ×îG¨
%šZ�¦?�ÉJf¤g?®y²gÚÉF#&˜Òs¼+¦H?�L0Uä5è3krãðŽ¹fÄè¾À‚þšÖ/jP§’EtJR(°l™'ö*hÈ„g	âaÈõ!¿çøßW µ4wèW¿z{k}#>'ôòp÷iŒ%†é„'.êšªÇí(ªœ²¶éÉÊ[òÝ[›¢ô¿rˆku0ª„	mL°Æz�‰ÉOþ9‹†ìIÆàÃàŽè¼érjö.�ÆúM"�ûeÀ}ÝöÓZd¶pŠ{	}6£ƒz)@ÊhÉÕ%‘1S°!ìGòIö¯$¹¡íÑÁe`Xª†º×·bG´*ú50­J8¼¯Ý–RÐ$¶®·�]õ¢ÖÏ&t	eFÝ�ÒÐŸÆ¼¢ø×–ŽÁVÝEÉ\À„PÏ–ïë6xçk¬C'è}Vìhú,ŸÎ®3îëÂGÈ*óY Ñ{U—B3JX6Ç6z‡×W+ »*'^´MÀº†UŽµþÓÒCZþjx×E—À9<Ê¹šJ“V÷Lìˆ7ÎìEiú�õp‹PöS`Úa×‚~ä¸þ¢Ö÷/§Ï›»•õ>±–_PÒrm|ÿ�(_qz§“Xõ^Rì×qnÿVh?w:Oþ`~s%¡ÂÂÎÒpÍ�ºÕ7pHA¿•cë˜Œ5î‹ÔMkÕÈÄL?€9Iœø‰züA5 /“úã]8¹m–a’}ÔÙGZŸ<¿5d'ã©ë-±^]"HUËño¥dJµ9¯Å?{š*Xæ2%Nù¥+Úhã²	¾>Èîùƒ¹ÿnßgð~‹ÝŠ+ç"¥›þOÃ1m	‡Â«7l‹D¼{@Ü®“¶Déo‚˜:H÷òõÙyÚã6p\÷½àªo�Ø6f7ªDÒêxÏ Á¬Sp˜IBá}?•Î­FJ^Îxeõk¼£„�ÏòŽø|üÇ$[ô8ƒ¹ªaþø=\@:˜É<Cê¸ë�üá=©žnùþH©¼Ü/Ñœ<+Ž;N)Ü®‘Yx‚#ÜoŸÉS¦¤ä `@XŸ—]^ßØÁš�¸¾¡µªl@PáQß?NiñõUY
¾3ŠÇÇ ÿ�¼e¬ˆãÐBy‰ÄA5Å­kh\qX`xX16ó|\ƒ¼¯j|(´" ˜?[Ñ¨úõÒq«TÏ/²¢:XdpPÞ>ƒø<¢ß©Ä?-ôÔÒ}cm
q0;ˆSVÈ×ƒ‹I÷ïrê×�¾›Å<Wy´.4õ÷Ü]vÕ7¤�ë±øëÝ¦v î&«dÈ�Äíž,ôÅˆÉíÚRØ¦]±ë˜–ºž±Ñ�ï~‰CNûN!Í®’Ã‹Ïåá_¤a¡UFl£‘NÅ¸óå¼¿IO‘‡XÀfQ~næ³˜³EÒüýP¸#4~)™æ·!K±6!u*ä
þ4ë6�ì¡‡‘C]øQBúaêŸÌý¹»i,8yÉW»™6žLH¿$×_EÐ-X+^¸–Sý–Ó/¯åVMæ¢PûÆÞt ëçw~š¢¯»NŸâ¢p_>AkTœ"àÓ¬Ø¡qÍm¦PRƒ¾QBnc²°$ëÿºZLì�8�¿±ûcpëò$}§P3Ý$­"‘Üßc…}š›G§O¹å©º#ÍÇRë®•19˜¿`Êò/ãbp\Ä.EÑZ4Õ_]Èƒ-±Á"ÀçÉTO³9á0Gs•ŽáM?ô#åÒ[KTbì_!p·|¯žE£’y£¿vŠíý´ ¦þ°b—Xf$Ó£ÉQºECƒ-ÜiÅŸáL¢@tU<Ò‘Í§jQaÚúô}]†�á’ŒrÎá,”üüÞ�£¢åý;§E¯H–CÖª<ãÀ(4^’bd$÷Ýp‚‘égÓj´ÙÎš¾”ÅØÖàØ 94¥�JˆêÍÒ‚ëÆ‰DˆzlÐë"ÍXA–b=?/ðªZ v54åæº�û•3 ç�ðom®îô‘âØH]Í�–Ü[ïÕæàÛå.‡&sm÷V7­˜5ÄqÓ½ÁáÈ©~×à ¦4YûÆ<Í°½…(ä#ouÏ�?ÿÄhn£Nòx¦ùÀÈÔh;É‹¤G½@´Z2±ãZ+¼È30;ËŽ3ÊØåÞ3%^ä_Éý¿œ2³Ã¹Pà8FlÕc¸Q*1Ì[Dl,•b°ÄŒ> �7?3‘�…#®Û^ˆâ:\dkèëÆo0l’¶ŒmKÝ=	Ë�È[Ò>'†–áq,,Îš€oi³ê(mkîíÙöDò#×n%žÁÔjF&ÿuiÍúŸIÀ¦@  «ús¹ÁuŸ¸ ð‰  y¥¦±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  �<?xml version="1.0"?><Features nextValidID="15"><Feature recentID="0" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5600-5704" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3411-3532" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2227-2362" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1335-1559" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2047-2376" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1605-2033" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3983-4568" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2443-3237" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="11" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5530" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4739-5530" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5531-5599" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="12" name="HOOK3(human)-circRNA" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="937-1279" color="#a6acb3" type="standard"/></Feature><Feature recentID="13" name="æ­£å�‘çŽ¯åŒ–ä»‹å¯¼åº�åˆ—" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="925-936" color="#a6acb3" type="standard"/></Feature><Feature recentID="14" name="å��å�‘çŽ¯åŒ–ä»‹å¯¼åº�åˆ—" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1280-1291" color="#a6acb3" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¨<Notes>
<UUID>c6ed9334-0a77-4a0d-893e-2d02bc433540</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-HOOK3(human)-circRNA-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="22:50:53">2025.7.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d               E              ÿÿÿÿYô? P                                                                                                                                                             í<StrandColors><TopStrand><ColorRange range="0..923" colors="black"/><ColorRange range="924..935" colors="light blue"/><ColorRange range="936..1278" colors="black"/><ColorRange range="1279..1290" colors="light blue"/><ColorRange range="1291..1974" colors="black"/><ColorRange range="1975..1976" colors="magenta"/><ColorRange range="1977..5767" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..923" colors="black"/><ColorRange range="924..935" colors="light blue"/><ColorRange range="936..1278" colors="black"/><ColorRange range="1279..1290" colors="light blue"/><ColorRange range="1291..1974" colors="black"/><ColorRange range="1975..1976" colors="magenta"/><ColorRange range="1977..5767" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
